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Cancer

Cancer Research

Overview

AdventHealth Cancer Institute's research initiatives include clinical research, translational and investigational research, and research in population health and value-based care as well as precision medicine and pharmacogenomics. 

Through cancer trials, doctors hope to find new ways to improve patients’ cancer treatments and quality of life. Clinical trials provide access to innovative and experimental therapies to patients with solid and circulating tumors, including through the National Cancer Institute’s Clinical Trials Network (NCTN). Our centralized clinical research team is comprised of research nurses, data managers, research assistants and regulatory coordinators.

Investigative research, including both “wet” translational and laboratory research as well as “dry” population health and value-based research, provides the ability to identify, develop and study new innovations in a real health system setting. While cancer care has already made tremendous progress, further innovation and research is necessary to develop and implement the next generation of therapeutics, best practices and disease preventions and targeted treatments targeted to the precise needs of the patient.

Contact Information

AdventHealth Cancer Institute
2501 N. Orange Avenue, Research Suite 683, Orlando, FL 32804

Areas of Focus

  • Brain & Spine Cancers
  • Breast Cancer
  • Digestive Tract Cancers
  • Gynecologic Cancers
  • Head, Neck & Skin Cancers
  • Leukemia, Lymphoma, Myeloma & Blood Cancers
  • Lung & Esophageal Cancers
  • Urologic Cancers

Featured Clinical Trials

MM-398-01-03-04

Icon for trial | MM-398-01-03-04

This study is currently enrolling.

This study will take place in 2 parts (Part 1 and Part 2). The purpose of Part 1 is to find out what is the best dose of irinotecan liposome injection to be used in Part 2 of the study. Once the best dose is found, Part 1 will ...

ML28897

Icon for trial | ML28897

This study is currently enrolling.

Many cancers contain molecular abnormalities (cells show biological and genetic changes in the laboratory) that cause or contribute to their ability to grow and spread. By blocking the effects of these abnormalities, the growth ...

APEC1621SC

Icon for trial | APEC1621SC

This study is currently enrolling.

The main purpose of this study is to learn how well tumors that have specific genetic changes (mutations) respond to drugs that target those changes. This combination of a tumor with a mutation and a drug that aims at that mut ...

Meet the Team

Our Capabilities

The specially trained team at the Blood and Marrow Transplant (BMT) Center has successfully performed more than 1,000 blood and marrow transplants, while providing therapy and treatment for a variety of blood-related cancers and diseases. The BMT Center is a member of the National Marrow Donor Program and certified by the Foundation for the Accreditation of Cellular Therapy for meeting stringent volume and standard of care requirements. The team participate in collaborative research across the country and around the world to bring innovative treatments to the patients.

Neuro-oncology is a specialty of neuro-oncologists, radiation oncologists and neurosurgeons that focus on the diagnosis and management of primary malignant/low-grade brain cancer and spinal tumors in adult and pediatric patients, other cancers that have traveled to the brain or spinal region, and treatment-related complications affecting the central or peripheral nervous system. The neuro-oncology program is certified in Gamma Knife radiosurgery and is on the forefront of innovative treatments and clinical trials.

Our advancements in diagnosis and treatment options, including minimally invasive breast cancer surgery and advanced imaging techniques, have won awards from some of the most noted organizations in cancer care. AdventHealth’s multidisciplinary and comprehensive approach to breast cancer care allows patients access to a team of breast cancer specialists at the Breast Cancer Clinic at the Altamonte and Orlando locations. The specialty team includes medical oncologists, radiation oncologists and breast cancer surgeons working together to develop targeted treatment plans and evaluate clinical trial options for patients based on their type of breast cancer and their individual needs.

Cellular Therapy Laboratory provides hematopoietic stem cells (HSCs) and other hematopoietic and non-hematopoietic cell types derived from a variety of sources for hematopoietic reconstitution and novel cellular therapies, including CAR T-cell.

Our team is made up of the country’s leading experts, who are focused on treating the entire scope of benign and malignant GI tumors, including anal, colon, GIST tumors, liver, rectal, stomach, pancreatic with an individualized, comprehensive approach. 

AdventHealth’s outstanding urology team in Central Florida makes this area a premier destination for the diagnosis and treatment of all types of urological disorders including complex conditions such as cancers of the bladder, kidney, adrenal, prostate, penis, and testicles.

From surgery to chemotherapy and revolutionary technology, like our MRI-guided HDR brachytherapy, your options range far and wide. And we’d be honored to help you choose.

Ranked among the top oncology programs nationwide, our gynecologic cancer team is recognized nationally for excellence in clinical research, minimally invasive robot-assisted surgery and training. Clinical research studies target cervical, fallopian tube, ovarian, uterine, endometrial cancers. AdventHealth Cancer Institute is the only location in Florida to offer clinical trials using an innovative immunotherapeutic oncolytic vaccinia virus for ovarian cancer.  

AdventHealth has one of the largest groups of leading otolaryngologists (ear, nose, and throat surgeons) in Central Florida. Collaboration between our surgeons, radiation oncologists, medical oncologists and other specialists is what makes us one of the country’s top-ranked oncology programs.

Our thoracic oncology specialists provide a comprehensive approach to the treatment and management of cancers of the lung, esophagus as well as lung nodules, mesothelioma, and thymoma. Personalized cancer treatment and clinical trials require a thorough understanding of cancer tissue genetics and the targeted therapies for identified genetic changes.  Clinical trials also focus on new drug combinations.

Our fully dedicated data management team has a strong working knowledge and skillset in clinical research data management principles and practices.

The pharmacists and technicians in our Investigational Drug Services (IDS) provide accountability, handling, storage, and control of investigational drugs and assure compliance with the standards of the FDA and of the study sponsors for inpatient and outpatient studies. We have two sites where drugs can be shipped: Celebration and Orlando.

This is a time for you and your family to focus on what’s most important, and that’s healing — not all the logistics that go along with cancer care. Clinical research care navigators (available at select locations) are here to help you schedule appointments, connect with your medical team, and assist with everything from financial questions to family conversations. Then there’s our integrated wellness network, with spas, social workers, and support groups, all geared to provide the care you need. We don't just fight your cancer with breakthrough science, clinical trials, and advanced diagnostics and treatments; we fight it by helping you stay brave, optimistic, and spiritually lifted at every step. When you're our patient, you’ll never be alone in this journey.

Services include:

  • Fresh or archived tissue availability. 
  • Ability to send blocks (instead of slides); if needed slides can also be sent by site. 
  • Utilize CT guided Biopsy for tissue collection for research.
  • Optional biopsies (for research only) are feasible providing sponsor agrees to budget requested and tumor is accessible by CT.

Services include:

  • EKG- Dedicated 12 lead EKG, ability to do own EKG’ with PI oversight. Alternatively, if the sponsor has their own machine they prefer us to use, we are more than capable of utilizing yours. 
  • The EKG machine is tagged and inspected by AdventHealth Biomedical Dept.

Services include:

  • Drugs can be shipped to Celebration or Orlando sites.
  • Hospital-based outpatient infusion: 80 chairs in Orlando, 28 chairs in Celebration.
  • Hospital-based (chemo certified) infusion room nurses administer the investigational product. The research nurses do not administer the investigational product, they create the study orders which are customized per protocol and signed by physician investigator. 
  • ARNP/PA cannot sign investigational orders.
  • Crash carts available with CODE access via 911 to hospitals (on-site at both Celebration and Orlando).
  • Freezers and refrigerators available.
  • All equipment tagged and inspected every six months by AdventHealth Biomedical Department.

Services include:

  • Ability to collect and process labs. Phlebotomist and research assistants on-site to coordinate processing.
  • Labs are all marked clinically significant/non-significant by investigators.
  • HIV test at screening can be done if required by study. AdventHealth has its own HIV consent form that is signed by all patients on study.

Services include:

  • Access to dedicated radiologist reads and dictates the report per RECIST criteria outlined in protocol. Experience with iRECIST. 
  • Access to GE Lightspeed RT 16 for CT scans. Slices are 5mm for abd/pelvis and 3.75mm for chest. The MRI machine used is GE Excite Echospeed 8 channel 1.5 Tesla.
  • Access to Outpatient CT scanner. Siemens, Somatom up 11101943 P81B, Software Version: VA10ASP.
  • Tumor measurements provided by radiology report are transferred to worksheet, reviewed by physician investigator and PI reviews/signs off on worksheet.

Intraoperative Radiation Therapy for breast cancer patients, which reduces damage done to healthy tissues and decreases (or eliminates) the number of post-surgery radiation treatments.  

Guided HDR Brachytherapy for prostate cancer patients, which is a minimally invasive outpatient procedure that limits your exposure to radiation through more targeted radiation therapy.

Robotic Prostatectomy for prostate cancer patients, in which our oncology surgeons guide a highly precise surgical tool to operate on delicate organs, for better outcomes and minimum side effects.

For brain and spine cancer patients, Gamma Knife® Radiosurgery allows our experts to remove tumors without affecting the surrounding healthy tissue. Our patients have experienced lower risks of side effects, faster recovery times, and better outcomes.

Aerial view of the AdventHealth Cancer Research Institute

About the Facility

AdventHealth Cancer Institute Orlando 

AdventHealth Orlando is an urban regional destination and high-volume trials site which specializes in all aspects of clinical trials and investigational research. It includes 80-bay hospital-based infusion chairs, investigational drug services, a clinical trials sample processing laboratory, CODE access to the hospital via 911, and other services.

AdventHealth Cancer Institute Celebration

The AdventHealth Celebration site is a national destination located adjacent to Disney theme parks with proximity to Universal Orlando Resort, LegoLand and other locations. The site specializes in all aspects of clinical trials with a focus on early-stage trials as a national destination site. The site includes state-of-the-art investigational drug services, CODE access to the hospital via 911, and other services. Includes 28-bay hospital-based infusion chairs, with future plans for expansion.

Satellite Sites

In addition to primary sites at Celebration and Orlando, AdventHealth can enroll and accrue patients at satellite sites such as Altamonte Springs, Kissimmee, Winter Park, and other locations. These sites include a range of services from full service, to primarily radiation, to ancillary services such as sample collection, laboratory testing and imaging.