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Bret H. Goodpaster, PhD

Bret H. Goodpaster , PhD

Scientific Director at the Translational Research Institute

Translational Research

Goodpaster

Overview

Bret Goodpaster, Ph.D. investigates the pathophysiology of human aging, obesity, insulin resistance, and diabetes, and the biological mechanisms underlying the health benefits of exercise.

Dr. Goodpaster has received a number of awards and honors for his work, including the Nathan Shock Award from the National Institute of Aging in 2008. He is particularly well known for “the athlete’s paradox” which has shifted the paradigm in type 2 diabetes research to investigate, how and why does fat accumulation in muscle cause insulin resistance in some subjects but not others? Which are the good fats and which are the bad fats?

Dr. Goodpaster has published >250 peer-reviewed papers, review articles and book chapters, has served on several Editorial Boards, and is currently an Associate Editor for Diabetologia. He has served on grant review panels for the NIH and the American Diabetes Association.

Dr. Goodpaster obtained a B.S. in Biology from Purdue, and after completing a Pre-doctoral Fellowship at Maastricht University in the Netherlands, received his Ph.D. in Human Bioenergetics from Ball State University. Prior to coming to the AdventHealth Translational Research Institute, he was Professor of Medicine and UPMC Chair for Diabetes and Metabolism Research at the University of Pittsburgh.

Articles

The Association of Skeletal Muscle Energetics With Recurrent Falls in Older Adults Within the Study of Muscle, Mobility and Aging

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

2024

Associations of Skeletal Muscle Mass, Muscle Fat Infiltration, Mitochondrial Energetics, and Cardiorespiratory Fitness With Liver Fat Among Older Adults

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

2024

Skeletal Muscle Energetics Explain the Sex Disparity in Mobility Impairment in the Study of Muscle, Mobility and Aging

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

2024

Associations Between D<sub>3</sub>Cr Muscle Mass and Magnetic Resonance Thigh Muscle Volume With Strength, Power, Physical Performance, Fitness, and Limitations in Older Adults in the SOMMA Study

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

2024

Chronic exercise improves hepatic acylcarnitine handling

ISCIENCE

2024

Signatures of cysteine oxidation on muscle structural and contractile proteins are associated with physical performance and muscle function in older adults: Study of Muscle, Mobility and Aging (SOMMA)

AGING CELL

2024

Exercise and ageing impact the kynurenine/tryptophan pathway and acylcarnitine metabolite pools in skeletal muscle of older adults

JOURNAL OF PHYSIOLOGY-LONDON

2023

The Study of Muscle, Mobility and Aging (SOMMA): A Unique Cohort Study About the Cellular Biology of Aging and Age-related Loss of Mobility

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

2023

Dual Roles of Cardiorespiratory Fitness and Fatigability in the Life-Space Mobility of Older Adults: The Study of Muscle, Mobility and Aging (SOMMA)

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

2023

Usual-paced 400 m long distance corridor walk estimates cardiorespiratory fitness among older adults: The Study of Muscle, Mobility and Aging

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

2023

Education & Training

Education

Ball State University, Muncie, IN

Fellowship

University of Pittsburgh, Pittsburgh, PA; Maastricht University in the Netherlands,

Associated Clinical Trials