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Bret H. Goodpaster, PhD

Bret H. Goodpaster, PhD

Scientific Director at the Translational Research Institute

Translational Research

Goodpaster

Overview

Bret Goodpaster, Ph.D. investigates the pathophysiology of human aging, obesity, insulin resistance, and diabetes, and the biological mechanisms underlying the health benefits of exercise.

Dr. Goodpaster has received a number of awards and honors for his work, including the Nathan Shock Award from the National Institute of Aging in 2008. He is particularly well known for “the athlete’s paradox” which has shifted the paradigm in type 2 diabetes research to investigate, how and why does fat accumulation in muscle cause insulin resistance in some subjects but not others? Which are the good fats and which are the bad fats?

Dr. Goodpaster has published >250 peer-reviewed papers, review articles and book chapters, has served on several Editorial Boards, and is currently an Associate Editor for Diabetologia. He has served on grant review panels for the NIH and the American Diabetes Association.

Dr. Goodpaster obtained a B.S. in Biology from Purdue, and after completing a Pre-doctoral Fellowship at Maastricht University in the Netherlands, received his Ph.D. in Human Bioenergetics from Ball State University. Prior to coming to the AdventHealth Translational Research Institute, he was Professor of Medicine and UPMC Chair for Diabetes and Metabolism Research at the University of Pittsburgh.

Articles

Exercise and ageing impact the kynurenine/tryptophan pathway and acylcarnitine metabolite pools in skeletal muscle of older adults

JOURNAL OF PHYSIOLOGY-LONDON

2023

The Study of Muscle, Mobility and Aging (SOMMA): A Unique Cohort Study About the Cellular Biology of Aging and Age-related Loss of Mobility

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

2023

Dual Roles of Cardiorespiratory Fitness and Fatigability in the Life-Space Mobility of Older Adults: The Study of Muscle, Mobility and Aging (SOMMA)

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

2023

Exerkines in health, resilience and disease

NATURE REVIEWS ENDOCRINOLOGY

2022

Skeletal muscle transcriptome response to a bout of endurance exercise in physically active and sedentary older adults

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

2022

State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions.

Comprehensive Physiology

2022

Intermuscular adipose tissue in metabolic disease

NATURE REVIEWS ENDOCRINOLOGY

2022

Mitochondrial Energetics in Skeletal Muscle Are Associated With Leg Power and Cardiorespiratory Fitness in the Study of Muscle, Mobility and Aging

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

2022

Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary

GEROSCIENCE

2022

Reply to 'Lactate as a major myokine and exerkine'

NATURE REVIEWS ENDOCRINOLOGY

2022

Education & Training

Education

Ball State University, Muncie, IN

Fellowship

University of Pittsburgh, Pittsburgh, PA; Maastricht University in the Netherlands,

Associated Clinical Trials