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Paul M. Coen, PhD

Paul M. Coen, PhD

Associate Investigator at the Translational Research Institute

Translational Research

Paul M. Coen

Overview

Dr. Paul Coen is an Associate Investigator at the Translational Research Institute for Metabolism and Diabetes, AdventHealth Orlando.

Paul’s research program is supported by the National Institutes of Health (NIH) and is broadly focused on elucidating the role of skeletal muscle mitochondrial energetics in the pathophysiology’s associated with aging and obesity.
Paul’s postdoctoral training was in the area of muscle metabolism under the mentorship of Dr. Bret Goodpaster at the University of Pittsburgh’s Division of Endocrinology and Metabolism (2008-2010). His postdoctoral work resulted in authorship on numerous peer-reviewed publications in high impact journals such as the Journal of Clinical Investigation, Diabetes, and Diabetes Care.

Originally hailing from Dublin, Ireland, Paul made the jump across the pond to study for a PhD in Exercise Physiology at Purdue University, which he completed in 2008. Prior to this, he completed an M.S. in Vascular Biology at the Vascular Health Research Center (VHRC) at Dublin City University (2004), and received his initial didactic and laboratory-based training with a B.Sc. in Bioanalytical Science from the Institute of Technology, Tallaght, Ireland (2000).

Articles

Skeletal muscle transcriptome response to a bout of endurance exercise in physically active and sedentary older adults.

American journal of physiology. Endocrinology and metabolism

2022

Weight Loss and Exercise Differentially Affect Insulin Sensitivity, Body Composition, Cardiorespiratory Fitness, and Muscle Strength in Older Adults With Obesity: A Randomized Controlled Trial

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

2021

A Novel Endocrine Role for the BAT-Released Lipokine 12,13-diHOME to Mediate Cardiac Function

CIRCULATION

2021

Sedentary and Trained Older Men Have Distinct Circulating Exosomal microRNA Profiles at Baseline and in Response to Acute Exercise

FRONTIERS IN PHYSIOLOGY

2020

Skeletal Muscle Energetics and Mitochondrial Function Are Impaired Following 10 Days of Bed Rest in Older Adults

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

2020

Older adults with sarcopenia have distinct skeletal muscle phosphodiester, phosphocreatine, and phospholipid profiles

AGING CELL

2020

Plasma lactate as a marker of metabolic health: Implications of elevated lactate for impairment of aerobic metabolism in the metabolic syndrome

SURGERY

2019

Metabolomics Analyses of Muscle Atrophy Induced by Hind Limb Unloading

METABOLOMICS: METHODS AND PROTOCOLS

2019

A MORE DYNAMIC NAME FOR AGE-RELATED FUNCTIONAL IMPAIRMENTS

JOURNAL OF APPLIED PHYSIOLOGY

2019

Platelet bioenergetics correlate with muscle energetics and are altered in older adults

JCI INSIGHT

2019

Education & Training

Education

Purdue University, West Lafayette, IN

Fellowship

University of Pittsburgh School of Medicine

Associated Clinical Trials