This is a randomized Phase III trial comparing a standard neoadjuvant chemotherapy regimen to an experimental neoadjuvant chemotherapy regimen that omits AC therapy. Both arms receive pembrolizumab for one year. If participants in the experimental arm have residual disease after neoadjuvant therapy, then they may receive adjuvant therapy post-surgery at physician discretion. This is a parallel randomization open-label design with equal allocation to the two treatment groups: (1) standard neoadjuvant chemotherapy and (2) neoadjuvant chemotherapy without AC. Randomization will be stratified by nodal status (negative or positive).