The purpose of this study is to determine whether a short-course radiation therapy option (3 to 4 weeks) after mastectomy is as safe and effective in the setting of breast reconstruction as the usual 5 to 6 week treatment cours ...

We are doing this study to test the safety and side effects of SGN-LIV1A and pembrolizumab when used together, as well as how well they work against triple-negative breast cancer that has spread to other parts of the body. We m ...

BYLieve: A phase II, multicenter, open-label, two-cohort,non-comparative study to assess the efficacy and safety of alpelisib plus fulvestrant or letrozole in patients with PIK3CA mutant, hormone receptor (HR) positive, HER2- n ...

This randomized phase III trial studies standard or comprehensive radiation therapy in treating patients with early-stage breast cancer who have undergone surgery. Radiation therapy uses high-energy x rays to kill tumor cells. ...

The purpose of this study is to compare any good and bad effects of using docetaxel along with the radiation therapy and hormone suppression therapy to using radiation and hormone suppression therapy alone in men with a high ch ...

The purpose of this research study is to compare any good and bad effects of using the study drug, crizotinib (also known as XALKORI), after completion of surgery and, in some cases, after chemotherapy and/or radiation therapy ...

The purpose of this research study is to examine lung cancer patients' surgically removed tumors for certain genetic changes, and to possibly refer these patients to a treatment study with drugs that may specifically target tum ...

This research study is a Phase III clinical trial, which tests the safety, tolerability and effect of an investigational combination of drugs to learn whether the combination of drugs works for a specific cancer. Investigationa ...

The primary purpose of this research study is to assess how metastatic or surgically unresectable Urothelial Carcinoma with FGF/FGFR alterations responds to treatment with INCB054828. The other goals of the study are to determi ...

The purpose of this study is to compare the effects, good and/or bad, of giving additional chemotherapy to you after the usual treatment of chemotherapy and radiation for your cervical cancer. The routine treatment for your typ ...

The purpose of this study is to (a) See if pembrolizumab in combination with chemotherapy and surgery is more effective than placebo with chemotherapy and surgery.

The purpose of this study is to find if adding the study drug, nivolumab (also known as OPDIVO), after standard chemotherapy {(mitomycin-C and 5-fluorouracil 5(-RU) or capecitabine) or 5-FU and cisplatin} and radition will prev ...

The purpose of this study is to see if apalutamide (also known as JNJ-56021927) plus androgen deprivation therapy (ADT), also known as hormone therapy, is safe and could improve the results of surgery and delay the time to when ...

The purpose of this study is to compare the effects of adding the drug nab-paclitaxel to the standard of care drugs cisplatin and gemcitabine versus cisplatin and gemcitabine alone. Nab-paclitaxel is an FDA-approved drug, but i ...

The purpose of this study is to learn if adding an experimental drug, atezolizumab (MPDL3280A), to a usual treatment or giving the experimental drug alone is better than the usual treatment alone.

The purpose of this study is to compare the usual treatment (usual chemotherapy plus bevacizumab) plus high-dose vitamind D3 to using the usual treatment plus regular-dose vitamin D3. The addition of high-dose vitamin D3 to the ...

The purpose of this study is to assess how the integration of a mobile application (Care4Today Connect), use of a survivorship care plan, and goal setting in the oncology clinic workflow can affect patients' health related ...

This study is being done to answer the following questions: (1) Will adding the drug daratumumab/rHuPH20 to the usual maintenance treatment with lenalidomide after stem cell transplant help myeloma patients survive longer?; and ...

The purpose of Part 2 is to determine whether the addition of talazoparib to enzalutamide provides additional benefit when compared to enzalutamide with placebo in subjects with your disease.

This study is being done to answer the following question: Can we determine whether to recommend chemotherapy or no further treatment after surgery for an early stage colon cancer, by taking a blood sample and testing for the p ...

We are doing this study to test if tucatinib plus T-DM1 works better to treat breast cancer than T-DM1 alone.

The purpose of this study is to compare the usual approach (no more treatment or additional chemotherapy and radiation therapy after surgery or radiation therapy alone after surgery), with any effects (good or bad) of receiving ...

The purpose of this study is to (a) test the safety of the study drug, pembrolizumab, when given with chemoradiotherapy (CRT). CRT is a combination of chemotherapy and radiation therapy; (b) see if pembrolizumab and CRT control ...

The purpose of this study is to compare the effects, good or bad, of an investigational anticancer drug called zanubrutinib (Z) (also known as BGB-3111) in combination with rituximab ®, versus commonly used treatment combinatio ...

This study is being done to learn more about if the new medication called capivasertib given with one of the standards of care fulvestrant will work more effectively than fulvestrant alone in treating patients with advanced bre ...

The purpose of this study is to (a) determine the highest dose that can safely be given without unacceptable (intolerable) side effects to subjects who have cancer; (b) determine the amount of OP-1250 in the blood of subjects w ...

The main purpose of this study is to compare getting more treatment with capecitabine (i.e. one of the usual approaches), to any good and bad effects of getting more treatment with a platinum-based chemotherapy (cisplatin or ca ...

The purpose of the study is to evaluate whether SAR439859 (our experimental hormonal treatment) is a better option compared to Letrozole (a standard hormonal treatment), when given together with Palbociclib (Ibrance), in terms ...

This trial is being done to test MK-6482 + lenvatinib in people with a type of kidney cancer called advanced clear cell Renal Cell Carcinoma (ccRCC). MK-6482 is still being researched and has not been approved to use alone or w ...

The purpose of the study is to find out if a new investigational drug, SAR408701, will have a significant activity in your disease. This will also allow to identify side effects associated with the use of SAR408701.

This trial is testing 3 combination therapies in people with a specific type of kidney cancer called advanced clear cell renal cell carcinoma (ccRCC). These 3 therapies are: (1) HIF triplet: pembrolizumab plus MK-6482 (belzutif ...

The purpose of this study is to test the effectiveness, safety and tolerability of nivolumab (Opdivo) given in combination with chemotherapy prior to definitive breast cancer surgery, followed by nivolumab with endocrine treatm ...

This study will explore the safety and the efficacy (how well it works) of an investigational drug talazoparib, when added to enzalutamide in patients with metastatic castration-sensitive prostate cancer (mCSPC).

Find out if the investigational drug sabatolimab (MBG453) is safe and effective (can help people) when combined with the currently approved treatment options in patients who have intermediate, high or very high risk myelodyspla ...

This is a randomized, double-blind, placebo-controlled, international, multicenter, phase 3 study designed to evaluate the efficacy and safety of tucatinib in combination with trastuzumab and pertuzumab as maintenance therapy i ...

This study is being done to answer the following question: Is treatment with hormonal therapy as good as the usual treatment of radiation and hormonal therapy in women with low-risk breast cancer who have had lumpectomy? We a ...

PHASE III TRIAL OF IMMUNOTHERAPY-BASED DRUG COMBINATION THERAPY WITH OR WITHOUT CYTOREDUCTIVE NEPHRECTOMY FOR METASTATIC RENAL CELL CARCINOMA (PROBE TRIAL) (Study SWOG 1931)

This study is being done to understand whether patients with a type of DLBCL known as non-germinal center diffuse large B-cell lymphoma (non-GCB DLBCL) will benefit from the addition of acalabrutinib to standard R-CHOP versus R ...

Participants will be invited to take part in this clinical research study if they have been treated for hormone receptor (HR)-positive and human epidermal growth factor receptor 2 negative (HER2)-negative breast cancer and have ...