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Senior Investigator
Translational Research
Dr. Gardell received his Ph.D. in Biochemistry from Cornell University Graduate School of Medical Sciences (NY, NY). His post-doctoral training in Molecule Biology was done at the University of California, San Francisco (UCSF), where he helped pioneer the use of site-directed mutagenesis to probe enzyme catalytic mechanisms. Dr. Gardell next spent 22 years in the drug discovery divisions of several major pharmaceutical companies (Merck, Bayer, Wyeth). The disease areas that were the target of his research pursuits included thrombosis, congestive heart failure, atherosclerosis, obesity, diabetes and Alzheimer’s disease. In 2009, Dr. Gardell joined the Sanford Burnham Prebys Medical Research Institute (SBP) in Orlando, Florida where he investigated an enzyme, nicotinamide phosphoribosyltransferase (NAMPT), which is the rate-determining step in NAD+ biosynthesis. He and his colleagues discovered small molecule activators of NAMPT that raise intracellular NAD+ levels, an effect with potential utility for a wide variety of diseases and healthy aging. While at SBP, Dr. Gardell also established a network of diverse technology cores and helped to direct the research operation. In May 2018, Dr. Gardell joined the Translational Research Institute in Orlando, Florida as a Senior Investigator where he continues his drug discovery research on NAMPT. In addition, Dr. Gardell established a Metabolomics Core at the TRI-MD which is a powerful technology platform to measure metabolites which serve to elucidate disease pathophysiology and unveil promising disease biomarkers..
FRONTIERS IN CARDIOVASCULAR MEDICINE
2024
NATURE COMMUNICATIONS
2024
CELL REPORTS
2023
JOURNAL OF PHYSIOLOGY-LONDON
2023
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
2023
NATURE AGING
2022
JOURNAL OF THE ENDOCRINE SOCIETY
2021
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2021
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2021
The American journal of clinical nutrition
2021
Cornell University, Graduate School of Medical Sciences, NY, NY
Nicotinamide adenine dinucleotide (NAD) is a vitally important substance that is found in all cells of the body. Elevated levels of NAD are linked to health and well-being. The key objective of this pilot research study is to ...