Steven R. Smith, MD
Chief Scientific Officer, Senior Vice President of the AdventHealth Research Institute
Translational Research
Overview
Dr. Steven R. Smith is Senior Vice President and Chief Scientific Officer of AdventHealth Research Institute guiding the research vision for AdventHealth. Smith also serves as the Associate Center Director, AdventHealth – Moffit Cancer Center Partnership. Smith’s scientific work within the TRI bridges the gap between cell/molecular biology and clinical care. Translational science involves translating discoveries in the basic sciences to the clinic and importantly informing basic science with clinical phenotyping and biospecimens.
Dr. Smith’s research is focused on obesity, diabetes and the metabolic origins of cardiovascular disease. He is specifically focused on how individuals differ in their ability to adapt to diets high in fat and understanding how obesity leads to type 2 diabetes. Using the translational medicine approach, Dr. Smith discovered that many obese people have an inability to burn fat and a new hormonal control system to increase fat and energy metabolism. Most importantly, the discovery that the inability to burn fat is programmed into muscle cells provides a novel way to identify and test new treatments for obesity and diabetes.
In the clinic, Dr. Smith has a special interest in the identification and development of drugs for the treatment of obesity and diabetes. His translational work demonstrated that each person is unique at the molecular level suggesting new ways to match therapies to the individual; this is the goal of field ‘personalized medicine.’
Articles
Physiology of Energy Expenditure in the Weight-Reduced State
Obesity
2021
Energy intake as a short-term biomarker for weight loss in adults with obesity receiving liraglutide: A randomized trial
OBESITY SCIENCE & PRACTICE
2021
A Novel Endocrine Role for the BAT-Released Lipokine 12,13-diHOME to Mediate Cardiac Function
CIRCULATION
2021
Integrative and quantitative bioenergetics: Design of a study to assess the impact of the gut microbiome on host energy balance
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
2020
Fat Distribution in Women Is Associated With Depot-Specific Transcriptomic Signatures and Chromatin Structure
JOURNAL OF THE ENDOCRINE SOCIETY
2020
An improvement in skeletal muscle mitochondrial capacity with short-term aerobic training is associated with changes in Tribbles 1 expression
PHYSIOLOGICAL REPORTS
2020
Plasma Myokine Concentrations After Acute Exercise in Non-obese and Obese Sedentary Women
FRONTIERS IN PHYSIOLOGY
2020
Endurance training remodels skeletal muscle phospholipid composition and increases intrinsic mitochondrial respiration in men with Type 2 diabetes
PHYSIOLOGICAL GENOMICS
2019
Metabolic adaptation is not observed after 8 weeks of overfeeding but energy expenditure variability is associated with weight recovery
AMERICAN JOURNAL OF CLINICAL NUTRITION
2019
Boosting NAD(+) with a small molecule that activates NAMPT
NATURE COMMUNICATIONS
2019
Education & Training
Education
University of Texas Health Science Center, San Antonio, TX
Residency
Baylor University Medical Center, Dallas, TX
Fellowship
Ochsner Clinic and Hospital, New Orleans, LA
Specialty
Obesity & Diabetes