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Steven R. Smith, MD

Steven R. Smith, MD

Chief Scientific Officer, Senior Vice President of AdventHealth

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S. Smith

Overview

Dr. Steven R. Smith is the Senior Vice President and Chief Scientific Officer of AdventHealth guiding the research vision for AdventHealth across the system. AdventHealth is a multi-state hospital system with 50 hospital campuses, more than 1,200 care sites and over 80,000 team members. Dr. Smith's oversight includes all research operations, services and oversight for the nine states in which we serve.

Dr. Smith earned his medical degree from the University of Texas Health Science Center in San Antonio, Texas in 1988. Smith completed his residency in internal medicine at Baylor University Medical Center in Dallas, Texas and subsequently completed a two-year fellowship in clinical endocrinology and metabolism at the Ochsner Clinic and Hospital in New Orleans, Louisiana. He was a faculty member at Pennington Biomedical Research Center for 15 years prior to joining AdventHeaIth.

Smith's scientific work bridges the gap between cell/molecular biology and clinical care. Translational science involves translating discoveries in the basic sciences to the clinic and importantly informing basic science with clinical phenotyping, biospecimens and modern molecular methods.

Smith's research is focused on obesity, diabetes and the metabolic origins of cardiovascular disease. He is specifically focused on how individuals differ in their ability to adapt to diets high in fat and understanding how obesity leads to type- 2 diabetes. Using the translational medicine approach, Dr. Smith discovered that many obese people have an inability to burn fat and a new hormonal control system to increase fat and energy metabolism. Most importantly, the discovery that the inability to burn fat is programmed into muscle cells provides a novel way to identify and test new treatments for obesity and diabetes. More recently, Dr. Smith's research program focuses on epigenetic programming of adipose tissue growth and function as well as the role of the human gut microbiome on the development of obesity. His translational work demonstrated that each person is unique at the molecular level suggesting new ways to match therapies to the individual; this is the goal of field 'personalized medicine.'

Dr. Smith's research is currently funded by the NIH with two RO1 Grants, industry and philanthropic support. In his research career, Dr. Smith has published more than 200 peer-reviewed scientific manuscripts, reviews and chapters.

Articles

Transcriptional and DNA Methylation Signatures of Subcutaneous Adipose Tissue and Adipose-Derived Stem Cells in PCOS Women

CELLS

2022

Caloric restriction in humans reveals immunometabolic regulators of health span

SCIENCE

2022

Physiology of Energy Expenditure in the Weight-Reduced State

Obesity

2021

Energy intake as a short-term biomarker for weight loss in adults with obesity receiving liraglutide: A randomized trial

OBESITY SCIENCE & PRACTICE

2021

A Novel Endocrine Role for the BAT-Released Lipokine 12,13-diHOME to Mediate Cardiac Function

CIRCULATION

2021

A Metabolomic Signature of Glucagon Action in Healthy Individuals With Overweight/Obesity

JOURNAL OF THE ENDOCRINE SOCIETY

2021

Twenty-four hour assessments of substrate oxidation reveal differences in metabolic flexibility in type 2 diabetes that are improved with aerobic training

DIABETOLOGIA

2021

Reliability of measurements of energy expenditure and substrate oxidation using whole-room indirect calorimetry

Obesity

2021

DNA Methylation as a Marker of Body Shape in Premenopausal Women

FRONTIERS IN GENETICS

2021

Developing a model for estimating the activity of colonic microbes after intestinal surgeries

PLOS ONE

2021

Education & Training

Education

University of Texas Health Science Center, San Antonio, TX

Residency

Baylor University Medical Center, Dallas, TX

Fellowship

Ochsner Clinic and Hospital, New Orleans, LA

Specialty

Obesity & Diabetes

Associated Clinical Trials

COVID-19

Icon for trial | COVID-19 Research

At AdventHealth our goal is to continue fighting COVID-19 until it is a thing of the past. Ongoing clinical trials and research studies help by contributing knowledge to the fight against COVID-19. 

NCT02226640

ORIGINS: Uncovering the ORIGIN’ of diabetes

Icon for trial | ORIGINS: Uncovering the ORIGIN’ of diabetes

The purpose of this study is to collect data to help researchers better understand the various causes of Type 2 Diabetes Mellitus (T2DM). This information may lead to T2DM treatment options that are more tailored to an individ ...