Paul M. Coen, PhD

Paul M. Coen , PhD

Associate Investigator at the Translational Research Institute

Translational Research

Paul M. Coen

Overview

Dr. Paul Coen is an Associate Investigator at the Translational Research Institute, AdventHealth Orlando.

Paul’s research program is supported by the National Institutes of Health (NIH) and is broadly focused on elucidating the role of skeletal muscle mitochondrial energetics in the pathophysiology’s associated with aging and obesity.
Paul’s postdoctoral training was in the area of muscle metabolism under the mentorship of Dr. Bret Goodpaster at the University of Pittsburgh’s Division of Endocrinology and Metabolism (2008-2010). His postdoctoral work resulted in authorship on numerous peer-reviewed publications in high impact journals such as the Journal of Clinical Investigation, Diabetes, and Diabetes Care.

Originally hailing from Dublin, Ireland, Paul made the jump across the pond to study for a PhD in Exercise Physiology at Purdue University, which he completed in 2008. Prior to this, he completed an M.S. in Vascular Biology at the Vascular Health Research Center (VHRC) at Dublin City University (2004), and received his initial didactic and laboratory-based training with a B.Sc. in Bioanalytical Science from the Institute of Technology, Tallaght, Ireland (2000).

Articles

Autophagy gene expression in skeletal muscle of older individuals is associated with physical performance, muscle volume and mitochondrial function in the study of muscle, mobility and aging (SOMMA)

AGING CELL

2024

The Association of Skeletal Muscle Energetics With Recurrent Falls in Older Adults Within the Study of Muscle, Mobility and Aging

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

2024

Associations of Skeletal Muscle Mass, Muscle Fat Infiltration, Mitochondrial Energetics, and Cardiorespiratory Fitness With Liver Fat Among Older Adults

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

2024

Skeletal Muscle Energetics Explain the Sex Disparity in Mobility Impairment in the Study of Muscle, Mobility and Aging

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

2024

Associations Between D<sub>3</sub>Cr Muscle Mass and Magnetic Resonance Thigh Muscle Volume With Strength, Power, Physical Performance, Fitness, and Limitations in Older Adults in the SOMMA Study

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

2024

Age Is Associated With Dampened Circadian Patterns of Rest and Activity: The Study of Muscle, Mobility, and Aging (SOMMA)

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

2024

Childhood adverse life events and skeletal muscle mitochondrial function

SCIENCE ADVANCES

2024

The cellular bases of mobility from the Study of Muscle, Mobility and Aging (SOMMA)

AGING CELL

2024

Chronic exercise improves hepatic acylcarnitine handling

ISCIENCE

2024

Signatures of cysteine oxidation on muscle structural and contractile proteins are associated with physical performance and muscle function in older adults: Study of Muscle, Mobility and Aging (SOMMA)

AGING CELL

2024

More Publication Information

Education & Training

Education

Purdue University, West Lafayette, IN

Fellowship

University of Pittsburgh School of Medicine

Associated Clinical Trials

NCT03761446

REST: The role of type 2 diabetes on skeletal muscle atrophy and recovery following bed rest in older adults

This study is currently enrolling.

Study Purpose: To better understand the role of Type 2 Diabetes on skeletal muscle atrophy and recovery following bed rest. Study Duration: 14 weeks Study Commitment: 2 Screening Visits 5 Pre-Bedrest Visits 10 Consecutiv ...

NCT04168580

BATSR: BAT as a therapeutic for the metabolic and cardiac dysfunction with senescence

To obtain a better understanding of how metabolic and heart health change with aging. To be enrolled in this study, you must meet certain requirements. You may be eligible to participate if you meet the following criteria ...

NCT04057677

RECOVER: Exercise training as an intervention to improve muscle function and Recovery following bed rest in older adults with type 2 diabetes

The purpose of this research is to gather data on how exercise can help recovery of muscle mass, strength, and physical function after bedrest. Procedures for this study include gathering medical history information, vital sig ...