Heart, Lung & Vascular Research Institute
Clinical Trials
DiuRetics Alone vs. AortIx ENdovascular Device for Acute Heart Failure (DRAIN HF)
This study is currently enrolling.
The purpose of this research is to evaluate the investigational Aortix System. The Aortix System is not approved by the FDA. The system has been designed for use in patients hospitalized with heart failure (HF) who still have s ...
HYPERION A Phase 3, Randomized, Doubleblind, Placebo-controlled Study to Evaluate Sotatercept When Added to Background Pulmonary Arterial
Hypertension (PAH) Therapy in Newly Diagnosed Intermediate-and High-risk PAH Patients
Hypertension (PAH) Therapy in Newly Diagnosed Intermediate-and High-risk PAH Patients
This study is currently enrolling.
Pulmonary arterial hypertension (PAH) is a disease affecting the blood vessels of the lungs. PAH leads to increased pressure in the blood vessels of the lungs which further leads to straining of the right side of the heart. You ...
Impact of Familial Hypercholesterolemia genetic testing on high-risk cardiovascular disease patient outcomes
This study is currently enrolling.
You are being invited to take part in a research study conducted by the AdventHealth Orlando in collaboration with Helix OpCo, LLC (“Helix”), a genetics company that performs the sequencing of DNA, and companies working with Ad ...
IMPAHCT: A Phase 2b/3, Randomized, Double-Blind, Placebo-Controlled, 24-Week Dose Ranging and Confirmatory Study to Evaluate the Safety and Efficacy of AV-101 in Patients with Pulmonary Arterial Hypertension (PAH)
This study is currently enrolling.
The purpose of this study is to evaluate what effects, good or bad, the investigational drug AV-101, comparedt to placebo, has on people with pulmonary arterial hypertension (PAH). In order to measure success for this study it ...
IMPROVE: MedStar Cardiovascular Research Network/IMPact on Revascularization Outcomes of intraVascular ultrasound guided treatment of complex lesions and Economic impact
This study is currently enrolling.
The study will assess whether the use of IVUS improves subjects’ clinical outcomes at 1 year following this PCI procedure. These subjects will be compared to subjects who did not undergo such IVUS imaging guidance during their ...
PHAR - Pulmonary Hypertension Association Registry
This study is currently enrolling.
We are asking you to be included in the Pulmonary Hypertension Association (PHA) Registry (PHAR). This is a national project about people who have pulmonary hypertension (PH). We are asking you to participate because you have P ...
STRIKE-PE: A Prospective, Multicenter Study of the Indigo Aspiration System Seeking to Evaluate the Long-Term Safety and Outcomes of Treating Pulmonary Embolism
This study is currently enrolling.
Your study doctor has determined you have or have had a pulmonary embolism (PE). A PE is a blood clot in an artery or arteries in your lung. A clot can be life threatening if immediate action is not taken to resolve it. At this ...
The SPYRAL AFFIRM Global Clinical Study of Renal Denervation with the Symplicity Spyral Renal Denervation System in Subjects with Uncontrolled Hypertension (SPYRAL AFFIRM)
This study is currently enrolling.
The purpose of this study is to study renal denervation with the Symplicity Spyral Renal Denervation system in patients with varying severity of uncontrolled high blood pressure and associated conditions. The focus of this stud ...
ADVANCE EXTENSION - A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects with PAH via an Open-Label Extension
If you have taken part in a research study with ralinepag, the investigational study drug, you may be able to take part in this extension study. This means that all participants will receive the investigational study drug to lo ...