Center for Pediatric Research
Clinical Trials
A Phase 3 Randomized Study of Selumetinib (IND# 77782) versus Carboplatin/Vincristine in Newly Diagnosed or Previously Untreated Neurofibromatosis Type 1 (NF1) Associated Low-Grade Glioma (LGG)
The overall goals of this study are to see if selumetinib works just as well as the standard treatment of carboplatin/vincristine (CV) for subjects with NF1-associated LGG, and to see if selumetinib is better than CV in improvi ...
A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors
Low Risk Subjects (Age <50 Years): The overall goal is to see if monitoring subjects with low risk germ cell tumors after their tumor is removed is as effective as following surgery with chemotherapy and/or more surgery. Sta ...
AL49: Tolerance of Infants Fed a Hydrolyzed Infant Formula
The purpose of this study is to evaluate the growth, tolerance and compliance of an intended use population of infants being fed an extensively hydrolyzed rice-based powdered infant formula (Similac® Arize) with 2’-FL HMO, DHA, ...
Children's Hospitals Neonatology Consortium (CHNC): Data Sharing and Quality Improvement Initiative
The complex high acuity-patient population seen in tertiary NICU's located in major children's hospitals across the nation is a unique predominately referral population, not seen in most NICU's supported by in-ho ...
Conservative Fluid Management in the First Week of Life Reduces the Risk of Prolonged Hemodynamically Significant Patent Ductus Arteriosus in Extremely Preterm Infants
To retrospectively collect and analyze the data to show that a change in practice at the Advent Health Orlando Neonatal Intensive Care Unit (NICU), implementing conservative fluid intake during the first week of life will reduc ...
Elevation of the Fetal Buttocks Prior to External Cephalic Version
In this study, we will analyze the available NICU data to determine the predictive value of a Bronchopulmonary Dysplasia (BPD) scoring system. Later, we will determine a threshold score at which an intervention like postnatal s ...
Establishment of the Pediatric Obesity Weight Evaluation Registry
The purpose of this study is to create a bank of information and outcomes for patients who are part of a weight management program using data collected from medical records.
Florida Neonatal Neurologic Network: A Retrospective Data Bank
The project will involve the creation of the Florida Neonatal Neurologic Network. This network will consist of major academic and private hospitals in North-Central Florida linked together with the purpose of creating a robust ...
International Phase 3 Trial in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Ph+ ALL Testing Imatinib in Combination with Two Different Cytotoxic Chemotherapy Backbones
The major goal of Induction therapy is to use a combination of chemotherapy drugs to try to eliminate as many of the leukemia cells as possible. We will also collect information from you that may be used to help further define ...