Translational Research Institute
Clinical Trials
ATLAS: Assessments of Adipogenesis, Lipid Turnover and Cellular Composition in Adipose Tissue in Response to Endurance
This study is currently enrolling.
The purpose of this research study is to study the effects of endurance exercise training on adipose (fat) tissue quality and insulin resistance in people with obesity. To be enrolled in this study, you must meet certain requi ...
AVAIL: AdventHealth Research Institute Non-Alcoholic Fatty Liver Disease Biobank and Registry
This study is currently enrolling.
Non-alcoholic fatty liver disease (NAFLD) is a common liver disease that leads to many health complications. Many people have this disease and do not know it. There are no medications available to treat it. The purpose of this ...
COMET: ImpaCt Of Shiftwork on METabolic Flexibility and Skeletal Muscle Clocks.
This study is currently enrolling.
Study Purpose: To determine how working a nighttime shift impacts your metabolism. To be enrolled in this study, you must meet certain requirements. You may be eligible to participate if you meet the following criteria: Study ...
CT-868-004
A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of CT-868 Administered for 16 Weeks to Overweight and Obese Adult Participants with Type 1 Diabetes Mellitus
A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of CT-868 Administered for 16 Weeks to Overweight and Obese Adult Participants with Type 1 Diabetes Mellitus
This study is currently enrolling.
Study Purpose: To evaluate the safety and tolerability of the study drug, CT-868, and to study the effect that CT-868 has on Type 1 Diabetes and weight. To be enrolled in this study, you must meet certain requirements. You may ...
DREAM: Diabetes RElated to Acute pancreatitis and its Mechanisms (DREAM). An observational cohort study from the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC)
This study is currently enrolling.
Study Purpose: The purpose of this research study is to find out how many people with acute pancreatitis develop diabetes. Risk factors for diabetes and the types of diabetes that occur after acute pancreatitis will also be st ...
ENABLE - Accessible testing of islet autoantibody may improve the clinical management of type 1 diabetes. We propose to validate the detection of islet autoantibodies for type 1 diabetes in self-collected capillary dried blood spot samples. Capillary blood spots do not require a visit to the doctor office and can be done without a phlebotomist, thereby lowering the testing barrier compared to venous blood draws. The assay performances will be compared to matching serum samples collected from the same individuals tested with FDA-cleared devices. The successful validation of the sample collection kit and assay may lead to the first regulatory-cleared assays for islet autoantibodies in self-collected sample types.
This study is currently enrolling.
Study Purpose: Clinical validation of islet autoantibody measurement in self-collected dried blood spot specimens. To be enrolled in this study, you must meet certain requirements. You may be eligible to participate if yo ...
EX-BOOST: Exercise to boost response to checkpoint blockade immunotherapy
This study is currently enrolling.
Study Purpose: To obtain a better understanding on how exercise can improve outcomes for patients with skin cancers. To be enrolled in this study, you must meet certain requirements. You may be eligible to participate if you me ...
EXPET: Dynamic in vivo PET imaging and ex vivo biopsies from skeletal muscle and adipose tissue to investigate the effects of exercise on insulin resistance and mitochondrial energetics in type 2 diabetes
This study is currently enrolling.
The overall aim of this study is to investigate the effects of exercise training on skeletal muscle and adipose tissue insulin resistance in subjects with Type 2 Diabetes (T2D).
FABULINUS: A 52-week randomized, double-blind, placebo controlled, multi-center Phase 2b study with a 52-week blinded extension assessing safety and efficacy of frexalimab, a CD40L-antagonist monoclonal antibody, for preservation of pancreatic beta-cell function in adults and adolescents with newly diagnosed type 1 diabetes on insulin therapy.
This study is currently enrolling.
Study Purpose: The study is aimed to evaluate an investigational drug, frexalimab, for preservation of pancreatic beta cell function in adults and adolescents that have been newly diagnosed with Type 1 Diabetes and started on i ...