Translational Research Institute
Clinical Trials
FABULINUS: A 52-week randomized, double-blind, placebo controlled, multi-center Phase 2b study with a 52-week blinded extension assessing safety and efficacy of frexalimab, a CD40L-antagonist monoclonal antibody, for preservation of pancreatic beta-cell function in adults and adolescents with newly diagnosed type 1 diabetes on insulin therapy.
This study is currently enrolling.
Study Purpose: The study is aimed to evaluate an investigational drug, frexalimab, for preservation of pancreatic beta cell function in adults and adolescents that have been newly diagnosed with Type 1 Diabetes and started on i ...
FINE-ONE: A parallel-group, randomized, prospective, interventional, double-blind, multicenter global Phase 3 study to investigate the efficacy and safety of Finerenone versus placebo, in addition to standard of care, in participants with chronic kidney disease and type 1 diabetes
This study is currently enrolling.
Study Purpose: The aim of the study is to demonstrate efficacy of Finerenone when compared to placebo, in addition to standard of care, in delaying the progression of chronic kidney disease (CKD) in participants with CKD and T1 ...
GLADIATOR: A phase 3, multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of 400 mg twice a day oral ladarixin in patients with new-onset type 1 diabetes and a low residual β-cell function at baseline.
This study is currently enrolling.
The purpose of this study is to check and collect data of how the body absorbs, distributes and gets rid of the study drug in the blood during the first cycle of LDX0319 study treatment. These data will help improve knowledge a ...
HONEY: Development of novel biomarkers for the early diagnosis of type 1 diabetes
This study is currently enrolling.
The purpose of this study is to identify novel biomarkers in the early stage of Type 1 Diabetes as well as to follow disease progression in individuals with early onset T1D. To be enrolled in this study, you must meet certain ...
MATPET: Dynamic PET imaging in skeletal muscle and adipose tissue to explore mechanisms of peripheral glucose uptake in African American, Hispanic, and Caucasian Women
This study is currently enrolling.
Study Purpose: The objective of this study is to obtain a better understanding between skeletal muscle characteristics and the ability to metabolize glucose. AdventHealth is seeking African American, Hispanic and Caucasian wome ...
MoTrPAC: Molecular Transducers of Physical Activity Consortium
This study is currently enrolling.
The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to assess molecular changes that occur in response to physical activity (PA). To achieve this aim, a mechanistic randomized controlled trial (RC ...
Participe en un estudio de investigación remunerado sobre la prevención de la diabetes (MATPET).
This study is currently enrolling.
AdventHealth, en colaboración con el Dr. James P. DeLany, busca mujeres afroamericanas, hispanas y caucásicas que estén interesadas en participar en un estudio de investigación que tiene como objetivo comprender la relación ent ...
REST: The role of type 2 diabetes on skeletal muscle atrophy and recovery following bed rest in older adults
This study is currently enrolling.
Study Purpose: To better understand the role of Type 2 Diabetes on skeletal muscle atrophy and recovery following bed rest. Study Duration: 14 weeks Study Commitment: 2 Screening Visits 5 Pre-Bedrest Visits 10 Consecutive ...
REVITALIZE-1: A Prospective randomized, double-blind, sham-controlled, multi-center pivotal study to evaluate the efficacy and safety of Duodenal Mucosal Resurfacing (DMR) using the Revita system in subjects with type 2 diabetes on insulin therapy.
This study is currently enrolling.
Study Purpose: The purpose of this study is to demonstrate the efficacy and safety of the Fractyl DMR Procedure using the Revita System compared to a sham. To be enrolled in this study, you must meet certain requirements. You m ...